Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrokinetic fluid control in two-dimensional planar microfluidic devices.

Margaret A Lerch1, Stephen C Jacobson

  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, USA.

Analytical Chemistry
|August 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient septum formation is essential for chromosome segregation in <i>Bacillus subtilis</i> when SMC function is impaired.

bioRxiv : the preprint server for biology·2026
Same author

Constitutive, endogenous, fluorescent membrane reporters for dynamic cell cycle analysis in <i>Bacillus subtilis</i>.

bioRxiv : the preprint server for biology·2026
Same author

Polyanionic Sugars Drastically Affect Assembly of Human Papilloma Virus Virus-Like Particles.

ACS infectious diseases·2025
Same author

Effective Diameters of Virus-Like Particles Measured by Resistive-Pulse Sensing on In-Plane Nanopore Devices.

Analytical chemistry·2025
Same author

Speed Matters: Directed Assembly of Icosahedral HPV Virus-Like Particles.

Journal of the American Chemical Society·2025
Same author

Modular Anti-Counterfeit Tags Formed by Template-Assisted Self-Assembly of Plasmonic Nanocrystals and Authenticated by Machine Learning.

Advanced functional materials·2025
Same journal

Machine Learning-Assisted Label-Free SERS Decoding of Mitochondrial Molecular Dynamics in Ovarian Granulosa Cells during Aging.

Analytical chemistry·2026
Same journal

Revealing the Regulatory Interplay of NHE1 mRNA and Na<sup>+</sup> in Cancer Cells Using a DNA Nanosensor.

Analytical chemistry·2026
Same journal

Towards Cellular Resolution of Tryptic Peptides in Tissue Sections by MALDI MS Imaging: A Focus on Enzyme Application and Reproducibility.

Analytical chemistry·2026
Same journal

Bioinspired Bilayer Hydrogel Colorimetric Sensor Array for Low-Temperature Food Freshness Analysis.

Analytical chemistry·2026
Same journal

Quartz Crystal Microbalance-Based Point-of-Care Testing Systems: Principles, Device Design, and Applications.

Analytical chemistry·2026
Same journal

Heterojunction Gate-Empowered OPECT Aptasensing: A Valid Protocol for Realizing High Current Gain at Low Electron Donor Dependency.

Analytical chemistry·2026
See all related articles

We developed novel microfluidic devices for efficient two-dimensional sample transport. Four control channels effectively confined sample streams, enabling precise manipulation in microfluidic systems.

Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Biotechnology

Background:

  • Efficient sample manipulation is crucial for microfluidic applications.
  • Traditional microfluidic designs face challenges in two-dimensional sample transport and confinement.
  • Minimizing sample dispersion is essential for accurate analysis.

Purpose of the Study:

  • To design and evaluate microfluidic devices for efficient two-dimensional sample transport.
  • To investigate methods for precise sample stream confinement and routing.
  • To optimize microfluidic device geometry for improved performance.

Main Methods:

  • Utilized SIMION and COMSOL simulations to guide microfluidic device design.
  • Fabricated and tested microfluidic devices with varying numbers of control channels.

Related Experiment Videos

  • Evaluated sample stream width and concentration-to-width ratios under different electric field strengths.
  • Compared performance of single versus parallel channels for the second dimension.

    • Main Results:

    • Four control channels demonstrated superior sample confinement compared to one or two.
    • Optimized electric field ratios (EC/E1D) enhanced sample stream confinement.
    • Parallel channels in the second dimension achieved narrower stream widths (down to 120 microm).
    • Effective confinement and routing of both sample streams and plugs were achieved.

    Conclusions:

    • The developed microfluidic device design enables efficient two-dimensional sample transport and confinement.
    • The use of control channels and optimized electric fields significantly reduces sample dispersion.
    • The parallel channel design for the second dimension offers improved performance for microfluidic applications.