Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Angiocidin inhibitory peptides decrease tumor burden in a murine colon cancer model.

Catherine Liebig¹, Neeti Agarwal, Gustavo E Ayala

¹Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

The Journal of Surgical Research

|August 28, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Early continuous positive airway pressure versus surfactant therapy in preterm neonates with respiratory distress.

Bioinformation·2026

Same author

Liver-specific Expression of HIV-1 Viral Protein R Causes Hepatic Steatosis and Glucose Intolerance in Male Mice.

Journal of the Endocrine Society·2025

Same author

When physician supply does not meet patient demand: A looming epidemic in vascular and renal care for a community with the highest incidence of end-stage renal disease in the United States.

American journal of surgery·2024

Same author

Neonatal Intestinal Obstruction: Etiology, Management, and Outcomes in a Tertiary Care Center.

Cureus·2024

Same author

A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome.

Dermatology online journal·2024

Same author

Chromoblastomycosis Presenting as a Solitary Lesion in a Non-endemic Region.

Cureus·2024

Same journal

The Price of Progress: Cost Considerations in Hepatocellular Carcinoma Clinical Trials.

The Journal of surgical research·2026

Same journal

Sex Differences in Thrombin Generation Using Calibrated Automated Thrombogram in Patients With Peripheral Artery Disease.

The Journal of surgical research·2026

Same journal

Beyond the Ventilator: Risk Factors for "Trauma-Associated" Pneumonia in the Trauma Intensive Care Unit.

The Journal of surgical research·2026

Same journal

Impact of In-Network Versus Out-of-Network Fragmentation of Care on Long-Term Outcomes After Trauma.

The Journal of surgical research·2026

Same journal

A Mixed-Methods Study of the Variation in Routine Preoperative Clinic Utilization.

The Journal of surgical research·2026

Same journal

Impact of Social Support on Patient-Reported Outcomes in Cardiothoracic Surgery: A Systematic Review.

The Journal of surgical research·2026

See all related articles

Angiocidin, a key factor in tumor growth, is highly expressed in human colon cancer. New inhibitory peptides effectively reduced tumor size and burden in preclinical models, showing promise for colon cancer therapy.

Area of Science:

Oncology
Molecular Biology
Cancer Therapeutics

Background:

Angiogenesis and tumor progression are significantly influenced by angiocidin.
Two novel inhibitory peptides targeting angiocidin have been developed.
This study investigates angiocidin expression in human colon cancer and peptide efficacy.

Purpose of the Study:

To determine angiocidin expression levels in human colon cancer tissues.
To evaluate the therapeutic potential of angiocidin inhibitory peptides in a colon cancer model.

Main Methods:

A colon cancer tissue array from 159 specimens was analyzed for angiocidin expression via immunohistochemistry.
The efficacy of 6-mer and 25-mer angiocidin inhibitory peptides was assessed in a murine colon cancer model.

Related Experiment Videos

Tumor volume, burden (internal disease and health scores), and xenograft angiocidin expression were measured.

Main Results:

Angiocidin was overexpressed in 89% of primary colon tumors and 91% of positive lymph nodes; all liver metastases were positive.
Peptide treatment significantly improved health and internal disease scores in mice compared to controls (P = 0.001).
Primary tumor volume was reduced by 3-fold and 16-fold with 6-mer and 25-mer peptides, respectively (P = 0.001).

Conclusions:

Angiocidin is significantly overexpressed in human colon cancer, indicating its role in the disease.
Angiocidin-inhibitory peptides demonstrate good in vivo tolerability.
These peptides effectively reduce tumor volume and burden in preclinical models of human colon cancer.