np1: a computer program for dose escalation strategies in phase I clinical trials
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Updated: Jul 12, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
Andrew Kramar1, Nadine Houédé, Xavier Paoletti
1CRLC Val d'Aurelle-Paul Lamarque, Unité de Biostatistiques, Parc Euromedecine, 34298 Montpellier Cedex 5, France. andrew.kramar@valdorel.fnclcc.fr
Abstract:
The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose. However, for a particular trial, the implementation of these methods requires extensive computer programming. Standard 3+3 designs do not require this, but have shown to possess poor statistical properties. np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial. Several options allow the user to investigate operating characteristics under various scenarios.
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