Related Experiment Video
Updated: May 7, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Innate immune response triggers lupus-like autoimmune disease
1Departments of Chemical Physiology and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92014, USA.
Abstract:
Autoimmune disease is typically defined as an aberrant response of lymphocytes to self antigens that ultimately leads to tissue damage. Reporting in Immunity, Green et al. (2007) now show that mice lacking alpha-mannosidase II develop an autoimmune disease similar to lupus. Remarkably, this illness is precipitated by an innate immune response to altered self glycans that mimic molecular patterns found on pathogens.
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