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Related Experiment Video

Updated: Jul 12, 2026

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

Preservation of brainstem neurophysiological function in hydranencephaly.

¹Neurology Department, Harvard Medical School, Massachusetts General Hospital, Harvard Biological Laboratories, Cambridge, MA 02138, United States. allen_counter@harvard.edu

Journal of the Neurological Sciences

|August 28, 2007

Summary

This study assessed neurophysiological function in hydranencephaly using evoked potentials. Results indicate intact brainstem auditory pathways, suggesting preserved unilateral auditory function despite absent cortical responses.

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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Area of Science:

Neuroscience
Clinical Electrophysiology

Background:

Hydranencephaly is a rare congenital disorder characterized by the absence of cerebral hemispheres.
Assessing central neurophysiological function in such cases is crucial for understanding residual brain function.

Purpose of the Study:

To evaluate the preservation of central neurophysiological function in a patient with hydranencephaly.
To correlate electrophysiological findings with clinical observations of auditory responses.

Main Methods:

Utilized a comprehensive panel of evoked potentials: brainstem auditory evoked responses (BAER), auditory middle latency responses (MLR), cortical auditory evoked responses (CER), electroretinograms (ERG), visual evoked responses (VER), and somatosensory evoked responses (SER).
Stimulation included auditory (ear-specific), visual (strobe flash), and somatosensory (median and tibial nerves).

Main Results:

Normal BAERs were observed for right ear stimulation, but abnormal for the left.
Auditory MLR and CER were absent bilaterally.
Strobe ERGs were grossly normal, while strobe VERs were abnormal.
SER revealed significant conduction defects in the median nerve pathways and rostral to the lower spinal cord for tibial nerves.

Conclusions:

Brainstem electrophysiological measures demonstrated functional auditory afferent tracts and nuclei.
The findings suggest intact unilateral auditory function, supporting clinical observations of behavioral auditory responses in hydranencephaly, despite the absence of cortical processing.