Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addendum: Assessing suitable habitat for freshwater mussel reintroductions using 3D-printed subadultreplicates.

Scientific reports·2026
Same author

Atypical Postradiation Vascular Proliferation: A Rare Dermatologic Sequela of Breast Cancer Therapy.

Clinical breast cancer·2026
Same author

Assessing suitable habitat for freshwater mussel reintroductions using 3D-printed subadult replicates.

Scientific reports·2025
Same author

Analysis of the Impact of High Acuity Rehabilitation Beds in Reducing Readmission Rate to Acute Care.

American journal of physical medicine & rehabilitation·2025
Same author

Lipoblastoma-Related Volvulus in a Nine-Year-Old Female.

Cureus·2024
Same author

Endometriosis: A Malignant Fingerprint.

Journal of cancer research and therapeutic oncology·2021

Related Experiment Video

Updated: Jul 12, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Pediatric germ cell tumors.

Zachary Horton1, Marc Schlatter, Sarah Schultz

  • 1Helen Devos Children's Hospital, Grand Rapids Medical Education and Research Center, Michigan State University, Grand Rapids, MI 49503, USA.

Surgical Oncology
|August 28, 2007
PubMed
Summary

Pediatric germ cell tumors show improved survival with platinum-based chemotherapy. Research is ongoing to reduce treatment side effects while maintaining excellent outcomes for these rare childhood cancers.

Area of Science:

  • Pediatric Oncology
  • Cancer Genetics

Background:

  • Pediatric germ cell tumors (GCTs) are a varied group of neoplasms.
  • Most GCTs arise from sporadic mutations, but environmental factors and genetic changes may contribute.
  • Platinum-based chemotherapy has significantly enhanced survival rates for malignant GCTs in children.

Purpose of the Study:

  • To review the current understanding of pediatric germ cell tumors.
  • To discuss the impact of chemotherapy on survival outcomes.
  • To highlight ongoing research directions in treatment and prognostication.

Main Methods:

  • Review of clinical behaviors, treatment outcomes, and prognostic factors for pediatric GCTs.
  • Analysis of survival data based on tumor type, stage, and location.

Related Experiment Videos

Last Updated: Jul 12, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

  • Discussion of current research trends, including chemotherapy optimization and cytogenetic studies.

    • Main Results:

    • Survival rates for gonadal GCTs are high (≥95% for early stage, ≥85% for advanced).
    • Extragonadal GCTs generally have a poorer prognosis, with mediastinal GCTs having the worst outcomes (70% 4-year survival).
    • Current research aims to reduce chemotherapy's morbidity while preserving efficacy.

    Conclusions:

    • Pediatric germ cell tumors require tailored treatment based on stage and location.
    • Advances in chemotherapy have greatly improved survival, with ongoing efforts to minimize treatment toxicity.
    • Cytogenetic research offers potential for improved prognostication and targeted therapies.