Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients.

Jonathan Himmelfarb1, Stephen Phinney, T Alp Ikizler

  • 1Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA. himmej@mmc.org

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|August 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerated Diagnostic Pathways for Suspected Acute Coronary Syndrome in Practice: A Randomized Trial of 0/1-Hour vs 0/3-Hour Troponin Testing.

Journal of the American College of Cardiology·2026
Same author

Mineral, Bone, and Cardiovascular Disorders in CKD: The Case for a New Paradigm.

Kidney medicine·2026
Same author

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease.

Kidney international·2026
Same author

Independent association between acute kidney injury and kidney function trajectory.

Kidney international·2026
Same author

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.

medRxiv : the preprint server for health sciences·2026
Same author

Potential integration of multiple organs-on-a-chip for comprehensive drug-drug interaction prediction.

Expert opinion on drug metabolism & toxicology·2026
Same journal

Letter to the Editor: Development and validation of a prediction model for estimating 24-hour urinary sodium excretion using spot urine samples in adult patients.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same journal

Letter to the Editor: Evaluation of Amino Acid Kinetics During Low-Dose Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury: A Prospective Single-Center Study.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same journal

Letter to the Editor: Nutritional Parameters Associated With Hospital Mortality in Patients With Acute Kidney Injury.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same journal

Nutritional status in maintenance hemodialysis patients in a large Chinese region : a multi-center cross-sectional survey.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same journal

Response to Letter to the Editor: Advancing Artificial Intelligence in Renal Nutrition: The Need for Culturally Adaptive, Equity-Focused Frameworks Beyond Retrieval-Augmented Generation.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
Same journal

Letter to the Editor Regarding "Structured Appetite Assessment in Children with Chronic Kidney Disease".

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026
See all related articles

Gamma tocopherol and docosahexaenoic acid (DHA) supplementation reduced inflammation markers in hemodialysis patients. Further trials are needed to confirm if these antioxidants can decrease cardiovascular risk in this population.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Hemodialysis patients face increased cardiovascular risk, potentially due to oxidative stress and inflammation.
  • No definitive therapies currently exist to mitigate this heightened risk.

Purpose of the Study:

  • To investigate the impact of gamma tocopherol and docosahexaenoic acid (DHA) on inflammation and oxidative stress markers.
  • To assess the safety and tolerability of gamma tocopherol and DHA in hemodialysis patients.

Main Methods:

  • A randomized, double-blinded, placebo-controlled clinical trial was conducted.
  • Participants received capsules containing gamma tocopherol (308 mg) and DHA (800 mg) or a placebo.
  • Key markers measured included interleukin-6 (IL-6), white blood cell count, C-reactive protein, F(2) isoprostanes, and protein carbonyl content.

Related Experiment Videos

Main Results:

  • Gamma tocopherol and DHA significantly reduced IL-6 levels, white blood cell counts, and neutrophil fractions.
  • No significant changes were observed in C-reactive protein, F(2) isoprostanes, or protein carbonyls.
  • The treatment was well-tolerated, with no serious adverse events attributed to the active intervention or placebo.

Conclusions:

  • Gamma tocopherol and DHA supplementation are well-tolerated in hemodialysis patients.
  • These compounds demonstrate a potential to reduce specific biomarkers of inflammation.
  • Larger clinical trials are necessary to determine the efficacy of gamma tocopherol and DHA in reducing cardiovascular complications.