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Related Experiment Videos

Probiotics and autoimmunity: an evolutionary perspective.

E B Canche-Pool1, R Cortez-Gómez, R Flores-Mejía

  • 1Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala, Col. Sto. Tomás, México DF 11340, Mexico.

Medical Hypotheses
|August 28, 2007
PubMed
Summary
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Probiotics, beneficial microorganisms, may be declining due to modern practices, potentially increasing autoimmune disease risk. Restoring ancient symbiotic relationships could be key to human health.

Area of Science:

  • Microbiology
  • Immunology
  • Evolutionary Biology

Background:

  • Probiotics are microorganisms conferring health benefits, typically from commensal microflora.
  • Ancient cultural practices fostered symbiotic relationships and probiotic transmission.
  • Industrialization introduced practices disrupting this symbiosis.

Purpose of the Study:

  • To propose that probiotics are ancient symbiotic microorganisms.
  • To hypothesize that modern lifestyle changes negatively impact the human microbiome.
  • To link alterations in the gut microbiota to the rise in autoimmune diseases.

Main Methods:

  • Review of historical cultural practices related to microbial symbiosis.
  • Analysis of the impact of industrialization on human-associated microflora.

Related Experiment Videos

  • Correlation of microbiome shifts with autoimmune disease incidence trends.

    • Main Results:

    • Modern practices like C-sections, processed foods, and antibiotic overuse displace beneficial probiotics.
    • This microbial shift favors less adapted microorganisms lacking probiotic benefits.
    • A significant evolutionary-paced change in the human gut microbiome is occurring.

    Conclusions:

    • The decline of ancient probiotics due to modern practices may contribute to increased autoimmune diseases.
    • Restoring or supporting the transmission of long-term symbiotic microorganisms is crucial.
    • Further research is needed to validate the link between microbiome changes and autoimmune conditions.