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Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
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Seven-day artificial lung testing in an in-parallel configuration.

Hitoshi Sato1, Grant W Griffith, Candice M Hall

  • 1Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

The Annals of Thoracic Surgery
|August 28, 2007
PubMed
Summary

The MC3 Biolung artificial lung supported sheep for 7 days, showing stable blood gases and hemodynamics. Improvements in blood biocompatibility are needed for this thoracic artificial lung.

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Area of Science:

  • Biomedical Engineering
  • Cardiopulmonary Support
  • Medical Devices

Background:

  • The MC3 Biolung is an investigational thoracic artificial lung.
  • It is designed for acute respiratory insufficiency and as a bridge to lung transplantation.

Purpose of the Study:

  • To evaluate the feasibility of a 7-day support period with the MC3 Biolung in a sheep model.
  • To assess the device's impact on hemodynamics, blood gases, and organ function.

Main Methods:

  • Ten sheep received respiratory support from the MC3 Biolung for up to 7 days.
  • Continuous monitoring included hemodynamics, blood gases, blood cell counts, and organ function.
  • Post-experiment necropsy was performed on all animals.

Main Results:

  • Seven sheep completed the 7-day support period.
  • Stable cardiac output, mean arterial blood pressure, and arterial oxygen tension were maintained.
  • Arterial carbon dioxide tension remained within normal limits; however, elevated white blood cell counts and signs of kidney infarction were observed.

Conclusions:

  • The thoracic artificial lung demonstrated suitability for 7-day use.
  • Further research is required to enhance the blood biocompatibility of the artificial lung device.