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Updated: Jul 12, 2026
09:24
O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
Correction of aortic insufficiency with an external adjustable prosthetic aortic ring
Andrew Gogbashian1, Ravi K Ghanta, Ramanan Umakanthan
1Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
The Annals of Thoracic Surgery
|August 28, 2007
Summary
A novel external adjustable aortic ring effectively reduced aortic insufficiency (AI) by 86% in an ovine model. This less invasive device shows promise for treating AI caused by aortic root dilatation.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
Background:
- Aortic insufficiency (AI) often necessitates surgical intervention.
- Less invasive, valve-sparing options are crucial for patients with AI.
Purpose of the Study:
- To assess the feasibility of an external adjustable aortic ring in reducing AI.
- To evaluate this device in an ovine model of aortic root dilatation.
Main Methods:
- Aortic insufficiency was surgically induced in five sheep using a pericardial patch.
- An adjustable external nylon ring was placed around the aortic root.
Main Results:
- The external aortic ring significantly reduced the mean regurgitant orifice area by 86% (0.07 to 0.01 cm2).
- Regurgitant fraction decreased from 18% to 2% with the ring tightened.
- The device did not significantly impact stroke volume or aortic pressure.
Conclusions:
- An ovine model for acute AI due to aortic root dilatation was successfully established.
- The external adjustable aortic ring effectively eliminated AI in this model.
- This aortic ring may serve as a valuable adjunct for treating AI secondary to annular dilatation.
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