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Updated: Jul 12, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Is previous thoracic sympathectomy a risk factor for exertional heat stroke?
Alan D L Sihoe1, Raymond W T Liu, Alex K L Lee
1Division of Cardiothoracic Surgery, Department of Surgery, The University of Hong Kong, Grantham Hospital, Hong Kong SAR, China. adls1@excite.com
Abstract:
We report the case of a physically fit young man who presented with severe, life-threatening heat stroke after running a 10 km road race. He had previously received bilateral thoracic sympathectomy for axillary hyperhidrosis at another hospital, and was known to have upper body and limb anhidrosis. Thoracic sympathectomy can result in reduced sweating and disturbed peripheral vascular and heart rate responses. Patients should be warned that these mechanisms may play a role in the development of exertional heat stroke.
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Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Homeostatic Imbalances in Body Temperature
Sympathetic Activation

