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Thyroid autoimmunity and thyroid dysfunction in women with endometriosis
C A Petta1, M S Arruda, D E Zantut-Wittmann
1Human Reproduction Unit, Department of Obstetrics and Gynaecology, School of Medicine, Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6181, 13084-971 Campinas, Brazil. cpetta@attglobal.net
Human Reproduction (Oxford, England)
|August 28, 2007
Summary
This study found no significant difference in thyroid dysfunction or autoimmune thyroid disease prevalence between women with endometriosis and controls. Routine thyroid screening is not recommended for endometriosis patients.
Area of Science:
- Reproductive Endocrinology
- Immunology
- Thyroidology
Background:
- Endometriosis is potentially linked to autoimmune disorders like hypothyroidism.
- Previous research suggests a possible association between endometriosis and thyroid dysfunction.
Purpose of the Study:
- To compare the prevalence of thyroid dysfunction and autoimmune thyroid disease (AITD) in women with endometriosis versus a control group.
- To investigate if endometriosis stage or infertility history impacts thyroid health.
Main Methods:
- A cross-sectional study involving 148 women with endometriosis and 158 controls.
- Serum levels of TSH, free T4, anti-TPO, and anti-Tg antibodies were measured.
- Participants' age and medical history were recorded.
Main Results:
- No statistically significant difference in thyroid disorders (20.9% vs 26.5%) or AITD (14.9% vs 22.2%) between groups.
- Thyroid dysfunction and AITD frequencies were similar in endometriosis and control cohorts.
- Endometriosis stage and infertility were not associated with thyroid dysfunction or AITD.
Conclusions:
- The prevalence of thyroid dysfunction and AITD is comparable between women with and without endometriosis.
- Current evidence does not support routine thyroid screening for women diagnosed with endometriosis.
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