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Updated: Jul 12, 2026
09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Apoptosis in gingival overgrowth tissues
A Kantarci1, P Augustin, E Firatli
1Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, MA 02118, USA.
Journal of Dental Research
|August 28, 2007
Summary
Gingival overgrowth involves increased fibroblast proliferation and decreased apoptosis, particularly in fibrotic tissues. These changes in cell death and growth are linked to altered FOXO1 and caspase 3 expression, contributing to the condition.
Area of Science:
- Oral biology
- Cellular pathology
Background:
- Gingival overgrowth etiology is linked to the balance between cell proliferation and apoptosis.
- Fibrotic gingival lesions may exhibit altered fibroblast proliferation and cell death rates.
Purpose of the Study:
- To investigate fibroblast proliferation and apoptosis in gingival overgrowth.
- To test the hypothesis of stimulated proliferation and decreased apoptosis in fibrotic gingival lesions.
Main Methods:
- In situ measurement of apoptotic index, caspase 3, proliferative index, and FOXO1 expression.
- Histological assessment of inflammation in gingival tissues.
Main Results:
- Apoptosis was significantly decreased in all examined gingival overgrowth forms (p < 0.05).
- Fibroblast proliferation was significantly elevated, independent of inflammation (p < 0.05).
- Decreased apoptosis correlated with reduced FOXO1 and caspase 3 expression.
Conclusions:
- Increased fibroblast proliferation and decreased apoptosis contribute to gingival overgrowth.
- Altered expression of FOXO1 and caspase 3 may underlie the reduced apoptosis observed.
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Normal cells contain receptors that prevent them from being recognized by phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
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