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Drug delivery systems.

D H Robinson1, J W Mauger

  • 1College of Pharmacy, University of Nebraska, Omaha.

American Journal of Hospital Pharmacy
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

Advanced drug delivery systems offer targeted, efficient medication administration with reduced side effects. Pharmacists play a crucial role in managing these innovative systems for improved patient care.

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Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Pharmacology

Background:

  • Traditional drug delivery systems face limitations in targeting, dosing accuracy, and managing drug variability.
  • Emerging drug delivery technologies are crucial for both traditional pharmaceuticals and complex biotechnological products.
  • The pharmaceutical market for advanced delivery systems is experiencing rapid global growth.

Purpose of the Study:

  • To discuss new and emerging drug delivery systems for traditional and biotechnological drugs.
  • To outline the evolving role of pharmacists in the appropriate use of advanced drug delivery systems.
  • To highlight the advantages of advanced systems over traditional methods.

Main Methods:

  • Review of physical, chemical, biological, and mechanical strategies in advanced drug delivery.

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  • Discussion of innovations in oral, injectable, implantable, and noninvasive delivery routes.
  • Exploration of genetic engineering's impact on delivering protein, peptide, and chemoimmunoconjugate drugs.
  • Main Results:

    • Advanced systems provide selective drug targeting, improved dosing, and reduced toxicity.
    • Innovations include polymer-based oral systems, emulsions, particulate systems, and enzymatic control.
    • Noninvasive routes encompass transdermal, respiratory, intranasal, and other topical applications.

    Conclusions:

    • Advanced drug delivery systems offer significant therapeutic advantages, including enhanced efficacy and safety.
    • The expanding market necessitates novel strategies for delivering biotechnological drugs.
    • Pharmacists' roles are expanding to include administration, advanced compounding, pharmacokinetic monitoring, counseling, and research.