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Published on: January 10, 2025
Case of corneal melting associated with the use of topical nepafenac
Peter D Bekendam1, Julio Narváez, Madhu Agarwal
1Department of Ophthalmology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Purpose:
To report a case of corneal melting associated with the use of the topical nonsteroidal anti-inflammatory agent Nepafenac.
Methods:
Case report and literature review.
Results:
A 62-year-old woman with a complicated ocular history developed corneal melting associated with the use of Nepafenac. On discontinuation of Nepafenac, the melt rapidly resolved.
Conclusions:
Topical nonsteroidal anti-inflammatory agents have been associated with corneal ulceration and stromal melts. This is, to our knowledge, the first reported case involving the new agent, Nepafenac.

