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Outbreak of CTX-M-3-type extended-spectrum beta-lactamase-producing Enterobacter cloacae in a pediatric ward
Naohiko Moriguchi1, Yuka Itahashi, Nobutada Tabata
1Department of Pediatrics, Sakai Hospital, Kinki University School of Medicine, 2-7-1 Harayamadai, Sakai, Osaka 590-0132, Japan. naohiko@sakai.med.kindai.ac.jp
Abstract:
A first resistant strain of Enterobacter cloacae was isolated from a blood specimen in a pediatric patient with immature teratoma-developed sepsis after combination chemotherapy. The strain produced extended-spectrum beta-lactamase (ESBL), and the same ESBL-producing strains were detected in urine samples from other patients in the pediatric ward. All strains harbored genes for bla (CTX-M-3) by polymerase chain reaction (PCR) and sequencing analysis. Analysis of pulsed-field gel electrophoresis revealed that all strains were the same clonal type. These results suggest that ESBL-producing strains might be transmitted in the ward via contact among patients or medical staff.
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