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First isolation of blaIMP-7 in a Pseudomonas aeruginosa in Japan

Shuntaro Kouda1, Ryuichi Kuwahara, Masaru Ohara

  • 1Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, Hiroshima city 734-8553, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|August 28, 2007
PubMed

Insights

The first carbapenem-resistant Pseudomonas aeruginosa strain carrying the blaIMP-7 gene was isolated in Japan. This multidrug-resistant isolate showed resistance to most tested antibiotics.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Pseudomonas aeruginosa is an opportunistic pathogen.
  • Carbapenem resistance is a growing global health concern.
  • Metallo-beta-lactamases (MBLs) are important carbapenemases.

Observation:

  • A carbapenem-resistant Pseudomonas aeruginosa strain was isolated in Japan.
  • The isolate carried the metallo-beta-lactamase gene blaIMP-7.
  • This strain exhibited a multidrug-resistant phenotype.

Findings:

  • This is the first report of blaIMP-7 in a carbapenem-resistant Pseudomonas aeruginosa in Japan.
  • The isolate showed high-level resistance to multiple antibiotics.
  • Piperacillin was the only effective antibiotic tested against this strain.

Implications:

  • This finding highlights the emergence and spread of carbapenem resistance in Japan.
  • The presence of blaIMP-7 necessitates enhanced surveillance and infection control measures.
  • Urgent strategies are needed to combat multidrug-resistant Pseudomonas aeruginosa.

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