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Published on: May 29, 2020
Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients
Tawesak Tanwandee1, Sutep Wanichapol, Sasijit Vejbaesya
1Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand. sittw@mahidol.ac.th
Objective:
To investigate the association between HLA class II alleles and autoimmune hepatitis (AIH) type I in Thai patients.
Material And Method:
The clinical data of 50 autoimmune hepatitis patients type I (AIH) at Siriraj hepatitis clinic were analysed, 37 of whom were tested for HLA class II genotyping using polymerase chain reaction and sequence-specific oligonucleotide technique (PCR-SSO).
Results:
AIH is an uncommon chronic hepatitis in Thailand with females predominant. The HLA DRB1*0301, and DQA1*0101 were significantly associated with AIH patients when compared to controls; (OR = 3.92 [1.18-13.30], p 0.021, OR = 2.31 [1.13-4.73], p 0.019, respectively). When 18 patients with "definite" AIH were analysed, only HLA DRB1*0301 was still significantly associated with AIH (OR = 5.22, 95%CI = 1.28-20.92, p 0.015).
Conclusion:
HLA genotyping has shown that HLA DRB1*0301 and HLA DQA1*0101 were significantly associated with AIH.
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