Related Experiment Video

Updated: Jul 12, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

[Is it possible to cure a patient with mycosis fungoides? A case report]

Victor Antonio Guillermo-Villanueva1, Guillermo J Ruiz-Delgado, Luz del Carmen Tarín-Arzaga

  • 1Servicio de Hematología, Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León, México. anton757@hotmail.com

Gaceta Medica De Mexico
|August 29, 2007
PubMed

Insights

Sezary syndrome (SS) and mycosis fungoides (MF) are rare T-cell lymphomas with poor prognosis. Reduced intensity conditioning stem cell transplant offers a potential curative option, achieving complete remission in this case study.

Area of Science:

  • Oncology
  • Hematology
  • Dermatology

Background:

  • Sezary syndrome (SS) and mycosis fungoides (MF) are aggressive cutaneous T-cell lymphomas.
  • These conditions often present a poor prognosis despite current treatment modalities.
  • Complete remission is rarely achieved with conventional therapies.

Observation:

  • This case study focuses on a patient with SS/MF, a challenging hematologic malignancy.
  • Conventional treatments for SS/MF have limited efficacy and high relapse rates.
  • Bone marrow transplant has been explored, but high mortality led to reduced intensity conditioning (RIC) stem cell transplant.

Findings:

  • The study details the successful application of RIC stem cell transplant in managing SS/MF.
  • The patient achieved a complete and sustained remission following the transplant procedure.
  • This outcome highlights the potential of RIC stem cell transplant as a viable therapeutic strategy.

Implications:

  • RIC stem cell transplant may offer a promising avenue for treating refractory SS/MF.
  • This approach could significantly improve long-term outcomes for patients with these lymphomas.
  • Further research into stem cell transplantation for cutaneous T-cell lymphomas is warranted.

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