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Updated: Jul 12, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Malignancy arising in seborrheic keratosis: two cases report]
Amina Mekni1, Saadia Bouraoui, Nidhameddine Kchir
1Service d'immuno-histo-cytologie,. Institut Salah Azaïz, Tunis.
La Tunisie Medicale
|August 29, 2007
Summary
Seborrheic keratosis, typically benign, can rarely transform into skin cancers like Bowen's disease or squamous cell carcinoma, potentially linked to human papillomavirus. This highlights the importance of biopsy for accurate diagnosis.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Seborrheic keratosis (SK) is a common benign epidermal tumor.
- Malignant transformation of SK is exceptionally rare.
- Human papillomavirus (HPV) has been implicated in the malignant transformation of skin lesions.
Observation:
- Two cases of SK in middle-aged women were analyzed.
- Biopsies were performed to investigate the nature of the lesions.
- The patients were aged 58 and 60 years.
Findings:
- The first patient's SK biopsy revealed Bowen's disease (squamous cell carcinoma in situ).
- The second patient's SK biopsy showed invasive squamous cell carcinoma.
- These findings indicate a rare malignant transformation of seborrheic keratosis.
Implications:
- This underscores the necessity of histological examination for SK diagnosis.
- It highlights the potential for rare malignant transformation in SK.
- Further research into the role of HPV in SK malignant transformation is warranted.
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