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Clindamycin-induced Sweet's syndrome.

Brychan M Clark1, Diane C Homeyer, Kristen R Glass

  • 1Department of Infectious Diseases, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas 78236, USA. Brychan.Clark@lackland.af.mil

Pharmacotherapy
|August 29, 2007
PubMed
Summary
This summary is machine-generated.

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Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a rare condition. This case report highlights a probable link between clindamycin therapy and the development of Sweet's syndrome.

Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Acute febrile neutrophilic dermatosis, commonly known as Sweet's syndrome, is an uncommon inflammatory condition.
  • While various medications have been implicated, an association with clindamycin has not been previously documented.

Observation:

  • A 47-year-old female patient with type 2 diabetes mellitus and end-stage renal disease developed Sweet's syndrome.
  • The patient had recently received both oral and intravenous clindamycin for a dental infection.
  • Symptoms resolved within days of discontinuing clindamycin.

Findings:

  • The Naranjo adverse drug reaction probability scale indicated a probable causal relationship between clindamycin use and Sweet's syndrome.
  • This case represents the first reported instance of Sweet's syndrome associated with clindamycin therapy.

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Implications:

  • Clinicians should consider Sweet's syndrome in patients presenting with characteristic symptoms following clindamycin treatment.
  • Early diagnosis and discontinuation of clindamycin can lead to complete recovery, potentially obviating the need for anti-inflammatory treatments.