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Updated: Jul 12, 2026
09:49
Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
Published on: September 25, 2021
Modular co-evolution of metabolic networks.
Jing Zhao1, Guo-Hui Ding, Lin Tao
1School of Life Sciences & Technology, Shanghai Jiao Tong University, Shanghai 200240, China. zjane_cn@sjtu.edu.cn
BMC Bioinformatics
|August 29, 2007
Summary
Biological network topology influences protein evolution. The human metabolic network
Area of Science:
- Systems Biology
- Molecular Evolution
- Bioinformatics
Background:
- Biological networks display significant modularity, with topological modules often correlating with functional modules.
- The impact of molecular network modular topology on protein evolution is not well understood.
Purpose of the Study:
- Investigate the functional and evolutionary modularity of the Homo sapiens metabolic network.
- Analyze the topological organization of the human metabolic network.
Main Methods:
- Network decomposition analysis of the human metabolic network.
- Topological investigation of network modules.
Main Results:
- The human metabolic network exhibits a core-periphery modular structure, with core modules handling basic functions and peripheral modules specialized.
- Over half of the identified modules show co-evolutionary patterns and specific evolutionary ages.
- Peripheral modules evolve cohesively and at a faster rate than core modules.
Conclusions:
- Functional, evolutionary, and topological modularity are interconnected, reflecting evolutionary history and functional demands in metabolic network architecture.
- Systems-level analysis provides insights into gene evolution within a genome-scale network context.
- Offers a novel perspective on molecular evolution.
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