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Pseudomyxoma peritonei syndrome of appendiceal origin: an overview

Carol Brueggen1, Gayle Baird, Allison Meisheid

  • 1College of Medicine, Mayo Clinic, Rochester, MN, USA. brueggen.carol@mayo.edu

Clinical Journal of Oncology Nursing
|August 29, 2007
PubMed

Insights

Pseudomyxoma peritonei (PMP) is a rare condition causing mucin buildup in the abdomen, often from appendix tumors. While not typically spreading outside the belly, PMP is fatal due to organ compression.

Area of Science:

  • Gastroenterology and Surgical Oncology
  • Abdominal Malignancies

Background:

  • Pseudomyxoma peritonei (PMP) syndrome is an uncommon, slowly progressive malignancy.
  • It typically originates from the perforation of an appendiceal adenoma.
  • Characterized by extensive mucin accumulation within the peritoneal cavity.

Purpose of the Study:

  • To summarize the key features of Pseudomyxoma peritonei syndrome.
  • To outline the clinical presentation and pathological characteristics.
  • To review the available treatment modalities for PMP.

Main Methods:

  • Literature review of Pseudomyxoma peritonei syndrome.
  • Analysis of epidemiological and clinical data.
  • Synthesis of information on diagnosis and management.

Main Results:

  • PMP involves mucinous implants on peritoneal surfaces and omentum.
  • The condition rarely metastasizes beyond the abdominal cavity.
  • Fatal outcomes result from gastrointestinal tract obstruction due to mucin accumulation.

Conclusions:

  • Pseudomyxoma peritonei syndrome is a distinct clinicopathological entity.
  • Management requires a multidisciplinary approach.
  • Treatment options range from observation to aggressive surgical and chemotherapeutic interventions.

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