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Genetic deficiency of complement component C8 in the rabbit: evidence of a translational defect in expression of the
M Komatsu1, K Yamamoto, H Mikami
1Department of Animal Breeding and Genetics, National Institute of Animal Industry, Ibaraki, Japan.
Biochemical Genetics
|June 1, 1991
Abstract:
We examined the molecular basis for rabbit C8 alpha-gamma deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for alpha, beta, and gamma, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for alpha and gamma of the same size and amounts as normal rabbits. Thus, C8 alpha-gamma deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.