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Updated: Jul 12, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
Staying alive--naïve CD4(+) T cell homeostasis
Jared F Purton1, Jonathan Sprent, Charles D Surh
1Scripps Research Institute, La Jolla, CA 92037, USA.
Abstract:
The immune system must maintain a broad repertoire of naïve T cells in order to respond to the diverse range of pathogens that it will encounter over the course of a lifetime. Although it is known that contact with IL-7 is crucial for the survival of naïve T cells, the precise intracellular signals that mediate its effects remain obscure. An article in this issue of the European Journal of Immunology has found that IL-7 requires the coordinated action of multiple pathways to maintain naïve CD4(+) T cells.
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