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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Radiotherapy for multiple brain metastases from hepatocellular carcinomas
Nobuyuki Toshikuni1, Kazuhiko Morii, Michinori Yamamoto
1Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School, 2-1-80 Nakasange, Okayama, Japan. n.toshikuni@gmail.com
World Journal of Gastroenterology
|August 29, 2007
Summary
Whole-brain radiotherapy effectively treated brain metastases from hepatocellular carcinoma (HCC) in a liver cirrhosis patient. This approach improved neurological symptoms, enhanced quality of life, and prolonged survival, demonstrating its potential therapeutic value.
Area of Science:
- Oncology
- Neurology
- Radiotherapy
Background:
- Hepatocellular carcinoma (HCC) is a primary liver malignancy.
- Brain metastases from HCC are rare but associated with poor prognosis.
- Management of HCC brain metastases remains challenging.
Observation:
- A 78-year-old male with liver cirrhosis and multiple HCCs developed left hemiparesis.
- MRI revealed multiple ring-enhancing brain metastases in the cerebrum and cerebellum.
- No other organ metastases were detected.
Findings:
- Whole-brain radiotherapy (50 Gy) led to near-complete disappearance of metastatic lesions.
- Neurologic symptoms significantly improved, enhancing the patient's quality of life.
- The patient survived for over 12 months post-brain metastasis diagnosis.
Implications:
- Radiotherapy is a viable treatment option for select patients with HCC brain metastases.
- This case highlights the potential for improved quality of life and survival.
- Further research into optimal management strategies for HCC brain metastases is warranted.
