Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vertical Superior Epigastric Artery Perforator Flap for Autologous Breast Augmentation After Massive Weight Loss.

Plastic and reconstructive surgery·2026

Same author

Digital Cognitive Twins in mental health.

Nature. Mental health·2026

Same author

Assessing PRISM context domains and RE-AIM outcomes: data from use of the iterative PRISM webtool.

Implementation science communications·2026

Same author

Social determinants of health and temporospatial trends associated with Giardia duodenalis infection in Texas canines.

Scientific reports·2026

Same author

Mechanical and Bond Performance of Alkali-Activated Slag Concrete Incorporating Natural and Recycled Diatoms.

Materials (Basel, Switzerland)·2026

Same author

From Evaluation to Elevation: Standardized Letter of Evaluation Domains Tied to Future Emergency Medicine Chief Residents.

The western journal of emergency medicine·2026

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Extensive basal cell carcinoma with probable bone metastasis.

Carlos Rodriguez¹, Valeria Barriuso, Lawrence S Chan

¹John H. Stroger, Jr, Hospital of Cook County, Chicago, Illinois, USA.

|August 30, 2007

Summary

Metastasis of basal cell carcinoma (BCC) is rare, typically occurring in extensive head and neck lesions. This case highlights probable bone metastasis, a serious complication with poor prognosis.

More Related Videos

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Related Experiment Videos

Last Updated: Jul 12, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Area of Science:

Oncology
Dermatology
Pathology

Background:

Basal cell carcinoma (BCC) rarely metastasizes.
Metastatic BCC often arises from chronic, extensive lesions on the head and neck.
Distant metastases can involve lymph nodes, lungs, bone, and abdominal viscera.

Observation:

A case of extensive basal cell carcinoma with suspected bone metastasis is presented.
Clinical and radiographic findings were consistent with previously reported cases of osseous BCC metastasis.
The patient's family declined a confirmatory postmortem biopsy.

Findings:

The case demonstrates a rare instance of probable bone metastasis from basal cell carcinoma.
Histologic confirmation of bone metastasis was not obtained due to family refusal of postmortem biopsy.
The clinical presentation aligned with established patterns of BCC bone involvement.

Implications:

This case underscores the potential for basal cell carcinoma to metastasize to bone, albeit rarely.
Early detection and management of extensive BCC are crucial to prevent such advanced disease.
Further research into the mechanisms and management of metastatic BCC is warranted.