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[Fenvalerate affects sperm motility in SD rats].

Ling Song1, Yu-Bang Wang, Hong Sun

  • 1Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|August 30, 2007
PubMed
Summary

Fenvalerate (Fen) exposure directly impairs sperm motility in Sprague-Dawley (SD) rats. High concentrations significantly reduced sperm velocity and linearity, indicating potential reproductive toxicity.

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The Science of the total environment·2022

Area of Science:

  • Environmental toxicology
  • Reproductive toxicology
  • Mammalian reproductive physiology

Context:

  • Pesticide exposure is a growing concern for environmental and public health.
  • Understanding the specific mechanisms of pesticide toxicity on reproductive health is crucial.
  • Fenvalerate is a widely used synthetic pyrethroid insecticide.

Purpose:

  • To investigate the direct impact of fenvalerate on sperm motility parameters in vitro.
  • To assess dose-dependent and time-dependent effects of fenvalerate exposure on sperm function.
  • To evaluate specific motility parameters including curvilinear velocity (VCL), straight-line velocity (VSL), average path velocity (VAP), beat cross frequency (BCF), straightness (STR), and linearity (LIN).

Summary:

  • Sperm were isolated from Sprague-Dawley rats and exposed to varying concentrations of fenvalerate (0-64 micromol/L) for 1, 2, and 4 hours.

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  • Significant reductions in sperm velocity (VSL), beat cross frequency (BCF), straightness (STR), and linearity (LIN) were observed at 64 micromol/L after 1 and 2 hours.
  • At 4 hours, progressive declines in VCL, VSL, BCF, STR, and LIN were noted at 64 micromol/L, with VCL also significantly reduced at 16 micromol/L. VCL and STR showed time-dependent alterations.

    • Impact:

    • Fenvalerate exhibits direct toxicity to sperm, potentially affecting male fertility.
    • The findings highlight the need for caution regarding exposure to fenvalerate, particularly for reproductive health.
    • This study provides in vitro evidence of fenvalerate's adverse effects on sperm motility, contributing to risk assessment of pesticide exposure.