Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

291
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
291
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.9K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

493
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
493
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

770
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
770
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

448
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
448
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

831
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
831

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IMMUNIA: A Reasoning-Centered Framework for Immunoregulatory Surfaceome Discovery.

ACS pharmacology & translational science·2026
Same author

Assessment of tumor mutation burden based on whole-exome sequencing of extracellular vesicle-derived DNA from bronchoalveolar lavage fluid in advanced non-small cell lung cancer treated with pembrolizumab: a prospective, multicenter, observational study.

Translational lung cancer research·2026
Same author

Fibrate-Statin Combination Therapy and Change of Hepatic Steatosis-Related Indices in Patients with Dyslipidemia: A Retrospective Study Using Korean National Health Insurance Data.

Endocrinology and metabolism (Seoul, Korea)·2026
Same author

The effect of rapid improvement of blood glucose level on diabetic neuropathy in Korean people with diabetes mellitus.

Diabetes research and clinical practice·2026
Same author

Contemporary Type 2 Diabetes Guidelines: Converging Evidence, Diverging Strategies, and the Position of the Korean Diabetes Association Framework.

Endocrinology and metabolism (Seoul, Korea)·2026
Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.

Clinical and experimental emergency medicine·2026

Related Experiment Video

Updated: Dec 31, 2025

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

2.2K

Rifampin-induced hypothyroidism without underlying thyroid disease.

Dong-Lim Kim1, Kee-Ho Song, Jung Hyun Lee

  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.

Thyroid : Official Journal of the American Thyroid Association
|August 30, 2007
PubMed
Summary

Rifampin (RFP) can cause hypothyroidism, even in individuals without pre-existing thyroid conditions. This case highlights a rare side effect of this common antibiotic.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.3K
Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

81.7K

Related Experiment Videos

Last Updated: Dec 31, 2025

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

2.2K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.3K
Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

81.7K

Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • Rifampin (RFP) is an antibiotic known to induce hepatic microsomal enzyme activity.
  • Previous reports link RFP-induced hypothyroidism to underlying Hashimoto's thyroiditis.
  • The mechanism of RFP-induced thyroid dysfunction is not fully elucidated.

Observation:

  • A case of hypothyroidism was observed in a patient treated with Rifampin (RFP).
  • The patient had no history of autoimmune thyroid disease or Hashimoto's thyroiditis.
  • Thyroid function normalized after discontinuation of RFP.

Findings:

  • This report details a case of Rifampin (RFP)-induced hypothyroidism.
  • The hypothyroidism occurred in the absence of any pre-existing thyroid pathology.
  • This suggests RFP can directly impact thyroid function independently of autoimmune processes.

Implications:

  • Clinicians should consider RFP as a potential cause of hypothyroidism, irrespective of baseline thyroid status.
  • This finding broadens the understanding of drug-induced thyroid dysfunction.
  • Further research is warranted to explore the direct mechanisms of RFP on thyroid hormone regulation.