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Updated: Feb 5, 2026

Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
Published on: October 25, 2014
Insights on the functional role of chromatin remodelers in osteogenic cells
Dafna Benayahu1, Nitsan Shacham, Irena Shur
1Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Israel. dafnab@post.tau.ac.il
Abstract:
Control of eukaryotic gene expression requires interaction between sequence-specific transcription factors and their regulatory elements on the particular promoter. The dynamic alteration of chromatin structure regulates the accessibility of these elements in the genome and therefore contributes to the control of transcriptional activity. Here we discuss chromatin remodelling in the context of osteoblast lineage regulation. This review specifically highlights the role of the protein chromatin-related mesenchymal modulator (CReMM/CHD9), a recently identified chromatin remodeler, in osteogenic cell differentiation.
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