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Updated: Jul 12, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic control of tumor suppression

Stela S Palii1, Keith D Robertson

  • 1Department of Biochemistry and Molecular Biology, Shands Cancer Center, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA.

Critical Reviews in Eukaryotic Gene Expression
|August 30, 2007
PubMed

Insights

Epigenetic silencing of tumor suppressor genes, through DNA hypermethylation and histone modifications, drives cancer development. Understanding these epigenetic changes is crucial for developing new cancer therapies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic silencing of tumor suppressor genes is a key driver of cancer.
  • Cancer-specific CpG island hypermethylation and repressive histone modifications are increasingly studied.
  • Research integrates epigenetics, chromatin remodeling, and epigenome-altering drugs.

Purpose of the Study:

  • To review key findings on epigenetic control of tumor suppression.
  • To analyze the role of DNA hypermethylation and histone modifications in malignancy.
  • To discuss hierarchical control and interdependent regulation in tumor suppression networks.

Main Methods:

  • Literature review of epigenetic mechanisms in cancer.
  • Analysis of DNA hypermethylation and histone deacetylation/methylation profiles.
  • Examination of tumor stage, progression, and prognosis correlations.

Main Results:

  • Epigenetic alterations, including DNA hypermethylation and histone modifications, lead to tumor suppressor gene silencing.
  • These epigenetic changes correlate with tumor stage, progression, and patient prognosis.
  • Hierarchical and interdependent regulatory networks exist within cellular tumor suppression.

Conclusions:

  • Epigenetic loss of function is critical in malignancy.
  • Developing a human epigenome database is essential for translational research.
  • Integrating epigenetic data will advance multidisciplinary studies of tumor suppressor networks.

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