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Endogenous endophthalmitis: microorganisms, disposition and prognosis
Thomas Ness1, Klaus Pelz, Lutz Lothar Hansen
1Department of Ophthalmology, University of Freiburg, Freiburg, Germany. thomas.ness@uniklinik-freiburg.de
Acta Ophthalmologica Scandinavica
|August 30, 2007
Summary
Endogenous endophthalmitis, an eye infection from spreading microbes, often affects immunocompromised individuals. Prognosis varies by causative organism, with Candida infections having better outcomes than gram-positive bacteria or Aspergillus.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Endogenous endophthalmitis is a serious intraocular infection originating from bloodstream microbial spread.
- It can lead to severe vision loss and is associated with systemic conditions.
Purpose of the Study:
- To identify causative microorganisms in endogenous endophthalmitis.
- To analyze patient disposition and disease prognosis based on microbial etiology.
Main Methods:
- Retrospective analysis of 31 eyes from 28 patients treated for endogenous endophthalmitis between 1996 and 2006.
- Microbiological investigation to identify causative agents.
Main Results:
- Causative microorganisms were identified in 94% of cases.
- Candida species were the most common isolates (15 eyes), followed by gram-positive bacteria (11 eyes) and Aspergillus (2 eyes).
- Most patients had underlying severe diseases (e.g., immunodeficiency, diabetes) or were intravenous drug users.
Conclusions:
- Endogenous endophthalmitis is frequently linked to Candida infections, unlike postoperative endophthalmitis.
- Visual prognosis is strongly dependent on the causative microorganism, with gram-positive bacteria and Aspergillus infections leading to poor outcomes.
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