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Leukocyte-poor blood components: issues and indications.

B Lichtiger1, G F Leparc

  • 1Division of Laboratory Medicine, University of Texas M. D. Anderson Cancer Center, Houston.

Critical Reviews in Clinical Laboratory Sciences
|January 1, 1991
PubMed
Summary

Leukocyte-poor blood components (LPBC) are now standard for transfusions. They are indicated for preventing febrile reactions and cytomegalovirus (CMV) infection, despite added costs.

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Area of Science:

  • Transfusion Medicine
  • Hematology

Background:

  • Leukocyte-poor blood components (LPBC) are essential in modern transfusion practices.
  • Technological advancements facilitate the preparation of LPBC through simple procedures.

Purpose of the Study:

  • To outline the indications and preparation of LPBC.
  • To discuss the cost implications associated with LPBC preparation.

Main Methods:

  • Leukocyte depletion of red blood cells (RBC) or platelets by at least one log.
  • Utilizing filters, washing, and rinsing solutions in blood component preparation.

Main Results:

  • LPBC preparation involves specific procedures to reduce leukocyte content.
  • Additional costs are incurred due to the manipulation and processing of blood components.

Conclusions:

  • LPBC are indicated for patients experiencing nonhemolytic febrile transfusion reactions.
  • LPBC help delay alloimmunization to HLA antigens and prevent cytomegalovirus (CMV) infection.

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