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Changes in the immune system after moderate beer consumption.

Javier Romeo¹, Julia Wärnberg, Esther Nova

¹Grupo Inmunonutrición, Departamento de Metabolismo y Nutrición, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Annals of Nutrition & Metabolism

|August 30, 2007

Summary

Moderate beer consumption enhanced immune function in healthy adults, particularly in women. This study investigated the immunomodulatory effects of moderate beer intake on various immune parameters.

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Area of Science:

Immunology
Nutritional Science
Public Health

Background:

Epidemiological studies suggest moderate alcohol intake correlates with reduced morbidity.
Intervention studies are crucial to understand the underlying mechanisms.
The impact of moderate beer consumption on immune function, considering gender, requires further investigation.

Purpose of the Study:

To determine the effects of moderate beer consumption on the immune system of healthy adults.
To explore potential gender-specific differences in immune response to moderate beer intake.
To elucidate the immunomodulatory mechanisms of moderate beer consumption.

Main Methods:

A 30-day period of moderate beer consumption (330ml/women, 660ml/men) followed a 30-day alcohol abstinence.
Evaluated immune parameters included leukocyte and lymphocyte counts, T-lymphocyte subsets (CD3+, CD4+, CD8+), B lymphocytes (CD19+), and serum immunoglobulins (IgG, IgA, IgM).
Assessed delayed-hypersensitivity skin response (DHSR) and cytokine production (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha).

Main Results:

Moderate beer intake increased CD3+ T-cells in women.
Serum immunoglobulin levels (IgG, IgM, IgA) and several cytokines (IL-2, IL-4, IL-10, IFN-gamma) were elevated in both genders.
The ratio of IFN-gamma to IL-10 decreased, indicating a shift in cytokine balance.

Conclusions:

Moderate beer consumption exerts an immunomodulatory effect in a healthy adult Spanish population.
The observed immunomodulatory effects appear more pronounced in women than in men.
Moderate beer intake can influence immune cell populations and cytokine profiles.