Epidural abscess, discitis and vertebral osteomyelitis caused by Neiserria subflava

Area of Science:

• Microbiology
• Infectious Diseases
• Clinical Medicine

Background:

• Neisseria subflava is a common commensal bacterium residing in the human oropharynx.
• While generally considered non-pathogenic, Neisseria subflava has been implicated in various invasive infections.
• Reported invasive diseases include bacteremia, endocarditis, sepsis, meningitis, septic arthritis, and discitis.

Observation:

• This paper documents an unusual case of invasive infection.
• The presented case involves an epidural abscess, a rare manifestation of bacterial infection.
• The causative agent identified in this specific case is Neisseria subflava.

Findings:

• This study reports the first instance of an epidural abscess caused by Neisseria subflava.
• The findings highlight the potential for Neisseria subflava to cause severe, localized infections.
• This case expands the spectrum of known invasive diseases associated with Neisseria subflava.

Implications:

• Clinicians should consider Neisseria subflava in the differential diagnosis of epidural abscesses, especially in patients with oropharyngeal colonization.
• This case underscores the importance of recognizing the pathogenic potential of commensal organisms.
• Further research may be warranted to understand the mechanisms underlying Neisseria subflava's invasive capabilities.