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Updated: Jul 12, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
CD8 T cells and latent herpes simplex virus type 1: keeping the peace in sensory ganglia
Brian S Sheridan1, Jared E Knickelbein, Robert L Hendricks
1University of Pittsburgh, School of Medicine, Graduate Program in Immunology, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
Abstract:
Herpes simplex virus type 1 (HSV-1) infections represent a significant worldwide heath problem. The lack of an effective therapy to curtail reactivation of HSV-1 from a state of neuronal latency has lead to significant morbidity and mortality. Effective therapies to prevent reactivation must likely elicit a protective CD8 T-cell response that could act to prevent reactivation from sensory neurons prior to release of infectious virus at the periphery. This review focuses on the present understanding of how CD8 T cells maintain HSV-1 latency and how this knowledge could facilitate the generation of more effective therapeutic modalities.
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