Related Experiment Video
Updated: Jul 12, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Bone marrow-derived stem cells in wound healing: a review
Yaojiong Wu1, JianFei Wang, Paul G Scott
1Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Abstract:
Optimum healing of a cutaneous wound requires a well-orchestrated integration of the complex biological and molecular events of cell migration and proliferation, and of extracellular matrix deposition and remodeling. Several studies in recent years suggest that bone marrow derived stem cells such as mesenchymal stem cells, progenitor cells such as endothelial progenitor cells and fibrocytes may be involved in these processes, contributing to skin cells or releasing regulatory cytokines. Stem/progenitor cells may be mobilized to leave the bone marrow, home to injured tissues and participate in the repair and regeneration. Direct injection of bone marrow derived mesenchymal stem cells or endothelial progenitor cells into injured tissues shows improved repair through mechanisms of differentiation and/or release of paracrine factors. Enhanced understanding of these cells may help develop novel therapies for difficult cutaneous conditions such as non-healing chronic wounds and hypertrophic scarring as well as engineering cutaneous substitutes.
More Related Videos
Related Concept Videos
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells
Clinical Applications of Epidermal Stem Cells
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Tissue Renewal without Stem Cells
However, failure of such a system...
Regulation of Hematopoietic Stem Cells

