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Profile of cognitive impairment in chronic heart failure

Raymond L C Vogels1, Joukje M Oosterman, Barbera van Harten

  • 1Department of Neurology, Sint Lucas-Andreas Hospital, Amsterdam, The Netherlands.

Journal of the American Geriatrics Society
|August 31, 2007
PubMed

Insights

Cognitive dysfunction is common in patients with chronic heart failure (CHF). Executive function, memory, language, and mental speed are most affected, with disease severity and ApoE genotype being key factors.

Area of Science:

  • Cardiology
  • Neuropsychology
  • Genetics

Background:

  • Chronic heart failure (CHF) affects a significant patient population.
  • Cognitive impairment is increasingly recognized as a comorbidity in CHF.
  • Understanding the prevalence and correlates of cognitive dysfunction in CHF is crucial for patient management.

Purpose of the Study:

  • To determine the frequency and pattern of cognitive dysfunction in outpatients with chronic congestive heart failure (CHF).
  • To identify demographic and clinical factors associated with cognitive impairment in CHF patients.

Main Methods:

  • A case-control study design was employed.
  • Sixty-two outpatients with CHF, 53 cardiac controls, and 42 healthy controls underwent neuropsychological assessments.
  • Cognitive domains evaluated included mental speed, executive function, memory, language, and visuospatial function, with statistical analysis to identify predictors.

Main Results:

  • Twenty-five percent of CHF patients exhibited cognitive impairment, significantly higher than cardiac (15%) and healthy controls (4%).
  • Impairment was noted across executive function, memory, language, mental speed, and attention.
  • Independent predictors of cognitive impairment in CHF were estimated intelligence, New York Heart Association class, and the apolipoprotein (Apo)E epsilon4 allele.

Conclusions:

  • Cognitive dysfunction is prevalent in patients with chronic CHF.
  • Deficits are most prominent in executive function, memory, language, and mental speed.
  • Disease severity and ApoE genotype are significant determinants of cognitive impairment in chronic CHF.
Abstract

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