Related Experiment Video

Updated: Jul 12, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

AB0 system and D(Rh o) antigen frequencies in left ventricular hypertrabeculation/noncompaction in relation to

C Stöllberger, W Krugluger, M Winkler-Dworak

    International Journal of Cardiology
    |August 31, 2007
    PubMed

    Insights

    This study found no significant differences in blood group distribution among patients with left ventricular hypertrabeculation/noncompaction (LVHT). Blood group frequencies in LVHT patients minimally differ from the general Austrian population.

    Area of Science:

    • Cardiology
    • Genetics
    • Hematology

    Background:

    • Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality with a suspected genetic basis, characterized by prominent trabeculations and deep intertrabecular recesses.
    • This study aimed to investigate the frequencies of ABO blood group and D(Rh(o)) antigen in LVHT patients.
    • The research also sought to identify potential associations between cardiac/neuromuscular abnormalities and blood type, and compare these frequencies with the general Austrian population.

    Discussion:

    • Analysis revealed no significant differences in clinical, electrocardiographic, echocardiographic, or neuromuscular findings based on ABO blood groups in LVHT patients.
    • Similarly, no differences were observed when comparing D(Rh(o)) antigen-positive and negative LVHT patient groups.
    • The most frequent blood types among LVHT patients were 0 D(Rh(o)) positive (39%) and A D(Rh(o)) positive (34%).

    Key Insights:

    • LVHT patients exhibit no significant variations in blood group distribution compared to each other.
    • The distribution of ABO and D(Rh(o)) blood groups in LVHT patients shows only minimal differences when compared to the general Austrian population.
    • The study did not find a correlation between blood groups and the presence of cardiac or neuromuscular abnormalities in LVHT.

    Outlook:

    • Further research could explore specific genetic markers associated with LVHT beyond blood groups.
    • Investigating larger, diverse populations may reveal subtle associations not detected in this study.
    • Understanding the genetic underpinnings of LVHT can aid in early diagnosis and personalized treatment strategies.
    Abstract

    More Related Videos

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

    Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

    Published on: July 14, 2021

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

    Published on: July 20, 2022

    Related Concept Videos

    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    Rheumatic Heart Disease I: Introduction01:23

    Rheumatic Heart Disease I: Introduction

    Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    Cardiovascular System Abnormal Findings II: Auscultation01:25

    Cardiovascular System Abnormal Findings II: Auscultation

    Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
    Abnormal Heart Sounds
    Gallops:
    Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

    Aortic Regurgitation II: Clinical Features and Diagnostic Tests

    Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...