Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current progress in network research: toward reference networks for key model organisms.

Balaji S Srinivasan1, Nigam H Shah, Jason A Flannick

  • 1318 Campus Drive, Clark Center S251, Stanford, CA 94305, USA. balajis@stanford.edu

Briefings in Bioinformatics
|August 31, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-intelligence: a proposal for human-artificial intelligence collaboration for large language models in medical research.

The Lancet. Digital health·2026
Same author

Artificial Intelligence in Peripheral Artery Disease: A Science Advisory From the American Heart Association.

Circulation. Population health and outcomes·2026
Same author

Physician-Reported Safety Outcomes of AI-Generated Hospital Course Summaries.

JAMA network open·2026
Same author

A clinical environment simulator for dynamic AI evaluation.

Nature medicine·2026
Same author

Merlin: a computed tomography vision-language foundation model and dataset.

Nature·2026
Same author

Time-to-Event Pretraining for 3D Medical Imaging.

... International Conference on Learning Representations·2026
Same journal

STED: flexible cross-modal topic modeling infers cell-type-specific regulatory landscapes from bulk epigenomics.

Briefings in bioinformatics·2026
Same journal

A knowledge-guided deep learning framework for quantitative nucleic acid testing.

Briefings in bioinformatics·2026
Same journal

Optimal transport for label transfer in single-cell multi-omics integration.

Briefings in bioinformatics·2026
Same journal

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same journal

Evaluating completeness, coherence, and consistency of genome-scale function annotations.

Briefings in bioinformatics·2026
Same journal

Transformers for single-cell RNA sequencing: a survey.

Briefings in bioinformatics·2026
See all related articles

Systems biology research now integrates multiple genome-scale datasets, focusing on data integration and network alignment. Statistical methods and Bayesian approaches are key for validating network models and building reference networks for model organisms.

Area of Science:

  • Systems biology
  • Genomics
  • Bioinformatics

Background:

  • Genome-scale datasets are routinely collected, shifting systems biology research focus.
  • Previous focus on single-dataset clustering for static functional maps is outdated.

Purpose of the Study:

  • Review functional genomics datasets.
  • Discuss data integration and network alignment methods.
  • Describe network models for guiding experimental validation.

Main Methods:

  • Surveying available functional genomics datasets.
  • Reviewing methods for data integration and network alignment.
  • Utilizing Bayesian inference for network uncertainty.

Main Results:

Related Experiment Videos

  • Statistical methods are crucial due to high-throughput measurement noise.
  • Network integration and validation are guided by Bayesian principles.
  • Recent work focuses on using network models for experimental validation.

    • Conclusions:

    • Systems biology is advancing through data integration and network analysis.
    • A near-term goal is constructing rich reference networks for model organisms.
    • Bayesian frameworks provide a basis for network uncertainty and validation.