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Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
Published on: December 9, 2022
[Acute retinal necrosis: an adult disease visits pediatrics]
Juan P Torres T1, J Pablo López G
1Departamento de Pediatría, Hospital Luis Calvo Mackenna, Santiago, Chile. jptorres@med.uchile.cl
Insights
Acute Retinal Necrosis (ARN) is a severe vision-impairing condition often seen in immunocompromised adults due to herpes virus reactivation. This review covers ARN
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Context:
- Acute Retinal Necrosis (ARN) is a severe intraocular inflammation.
- ARN predominantly affects severely immunocompromised adult patients.
- Reactivation of herpes simplex virus (HSV) or varicella-zoster virus (VZV) is a common cause.
Purpose:
- To review the clinical and ophthalmological features of ARN.
- To outline recommended diagnostic strategies for ARN.
- To discuss current management approaches for ARN.
Summary:
- ARN presents with characteristic retinal and choroidal lesions.
- Diagnostic workup may include viral polymerase chain reaction (PCR) testing.
- Treatment involves antiviral therapy and often requires multidisciplinary management.
Impact:
- Improved understanding of ARN pathogenesis and clinical presentation.
- Enhanced diagnostic accuracy for timely intervention.
- Optimized management strategies to preserve vision in ARN patients.
Abstract:
Acute retinal necrosis (ARN) is a serious condition that can impair vision. It mostly occurs in adult patients, especially those severely immunocompromised, in association with a reactivation of a herpes virus infection. Clinical and ophtalmological features of ARN and recommended diagnostic and management strategies are reviewed.
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