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Related Concept Videos

Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Fixing Double-strand Breaks02:04

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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Fixing Double-strand Breaks02:04

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Homologous Recombination02:31

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Mismatch Repair

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
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Semi-permanent split end mending with a polyelectrolyte complex.

R Rigoletto1, Y Zhou, L Foltis

  • 1International Specialty Products, 1361 Alps Road, Wayne, NJ 07470, USA.

Journal of Cosmetic Science
|August 31, 2007
PubMed
Summary

A novel polyelectrolyte complex of Polyquaternium-28 and PVM/MA Copolymer effectively mends split ends semi-permanently. This hair repair solution demonstrates durability against combing and washing, offering a superior alternative to commercial products.

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Area of Science:

  • Cosmetic Science
  • Materials Science
  • Polymer Chemistry

Background:

  • Split ends are a common hair damage issue caused by mechanical stress, particularly from excessive combing.
  • Existing treatments lack permanent solutions for mending split ends, necessitating innovative approaches.

Purpose of the Study:

  • To develop and evaluate a novel semi-permanent split end mending composition using a polyelectrolyte complex.
  • To assess the durability and efficacy of the complex in repairing and mending split ends.

Main Methods:

  • Formation of a polyelectrolyte complex via ionic association between Polyquaternium-28 (cationic) and PVM/MA Copolymer (anionic).
  • Utilizing tagged split ends on hair tresses to monitor mending efficacy and durability after various treatments.
  • Employing stereomicroscopy, Scanning Electron Microscopy (SEM), viscometry, and ionic dye absorption for analysis.

Main Results:

  • The polyelectrolyte complex demonstrated significant split end mending capabilities, both alone and in a lotion formulation.
  • Mending efficacy proved durable after repeated combing and washing, indicating no significant buildup on hair.
  • The formulated lotion outperformed a leading commercial product in split end mending durability.

Conclusions:

  • A polyelectrolyte complex of Polyquaternium-28 and PVM/MA Copolymer offers an effective semi-permanent solution for split ends.
  • The proposed mechanism involves a crosslinking microgel structure that binds damaged hair sites.
  • This innovative treatment is suitable for post-shampoo application due to its rinse-off properties and durability.