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Updated: Jul 12, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

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Published on: May 8, 2016

FcgammaRIIB as a modulator of autoimmune disease susceptibility

Tatyana Tarasenko1, Jonathan A Dean, Silvia Bolland

  • 1Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, Rockville, MD 20852, USA.

Autoimmunity
|August 31, 2007
PubMed

Antibodies are secreted to recognize and in some cases directly neutralize pathogens. Another important means by which they are essential components of the immune system is through binding to Fc receptors. Effector responses triggered by antibody binding of Fc receptors affect a host of important cellular responses such as phagocytosis, inflammatory cytokine release, antigen presentation, and regulation of humoral responses. A crucial check on this antibody-mediated signal is through the inhibitory receptor, FcgammaRIIB. In this review we discuss how dysregulation of FcgammaRIIB can result in a lowered threshold for autoimmunity in mice and humans. We close with a discussion of the potential for applying these findings to immunotherapy.

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