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Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

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Bioavailability Enhancement: Drug Permeability Enhancement

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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Updated: Jul 12, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Current perspectives of solubilization: potential for improved bioavailability.

Subrata Mallick¹, Satyanarayan Pattnaik, Kalpana Swain

¹Formulation Development and Drug Delivery Systems, Department of Pharmaceutics, College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India. smallickin@yahoo.co.in

Drug Development and Industrial Pharmacy

|August 31, 2007

Summary

This summary is machine-generated.

This review explores drug solubilization techniques to enhance absorption and bioavailability. Factors like cosolvents, pH, ionic strength, and polymorphism significantly impact drug delivery and effectiveness.

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Last Updated: Jul 12, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

Pharmaceutical Sciences
Drug Delivery
Physical Chemistry

Background:

Drug solubility is a critical factor influencing absorption and bioavailability.
Various formulation strategies aim to overcome poor drug solubility.
Understanding solubilization mechanisms is key to effective drug design.

Purpose of the Study:

To review recent techniques for drug solubilization.
To discuss factors affecting solubilization efficiency.
To highlight the role of molecular modeling in predicting drug-excipient interactions.

Main Methods:

Review of literature on solubilization techniques.
Analysis of factors influencing micellar solubilization (pH, ionic strength).
Discussion of polymorphism's impact on dissolution.
Overview of molecular modeling for cyclodextrin complexation.

Main Results:

Cosolvent addition can alter drug crystal structure and decrease micellar solubilization capacity.
Ionic strength and pH significantly affect micellar solubilization.
Polymorphism is a key determinant of drug dissolution and bioavailability.
Molecular modeling can predict complexation behavior and efficiency.

Conclusions:

Effective drug solubilization requires careful consideration of formulation components and physical properties.
Techniques like micellar solubilization and cyclodextrin complexation offer potential for improved drug delivery.
Further research using molecular modeling can optimize drug formulation design.