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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Numerical simulation of in vitro pulsatile flow and its study using FRISK, a rapid phase contrast technique
Longchuan Li1, Mark Doyle, Geetha Rayarao
1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Journal of Magnetic Resonance Imaging : JMRI
|August 31, 2007
Summary
Fragmented regional interpolation for k-space (FRISK) is a novel MRI technique that halves scan times. This method captures complex blood flow details during a single breathhold, improving accuracy and resolution in cardiovascular imaging.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Medical Imaging Physics
- Fluid Dynamics in Medicine
Background:
- Phase contrast magnetic resonance (PC-MR) imaging is crucial for assessing complex blood flow.
- Conventional PC-MR techniques often require long scan times, limiting their clinical applicability, especially for breathhold acquisitions.
- Capturing intricate flow dynamics necessitates high spatial and temporal resolution, posing a challenge for accelerated imaging methods.
Purpose of the Study:
- To evaluate the efficacy of a novel sparse sampling technique, fragmented regional interpolation for k-space (FRISK), for PC-MR.
- To determine FRISK's ability to accurately capture complex flow features within a clinically feasible breathhold duration.
- To compare the performance of FRISK against conventional PC-MR using both numerical simulations and in vivo experiments.
Main Methods:
- Computational fluid dynamics (CFD) models were created, including a two-chamber orifice flow model, a femoral artery model, and a U-shaped aortic arch model.
- Simulations of conventional and FRISK PC-MR data acquisitions were performed using the CFD data.
- FRISK acquisition parameters were adapted to optimize for different flow field characteristics (temporal vs. spatial information).
- In vivo PC-MR imaging was conducted on a healthy volunteer to compare conventional and FRISK breathhold scans.
Main Results:
- Simulations demonstrated that FRISK maintained or improved data accuracy while reducing scan time by at least 50% compared to conventional PC-MR.
- FRISK successfully captured detailed in-plane and through-plane velocity information within approximately 20 heartbeats (breathhold duration) by adapting parameters.
- In vivo results corroborated simulations, showing FRISK breathhold imaging enhanced spatial resolution and maintained adequate temporal resolution compared to conventional breathhold PC-MR.
Conclusions:
- FRISK is a novel MRI sampling sequence that utilizes sparse data acquisition and postprocessing alignment.
- FRISK offers a significant scan time reduction (approximately factor of 2) compared to conventional PC-MR methods.
- This technique enables rapid or breathhold scanning while achieving acceptable accuracy for complex flow imaging.
