[Paeonia Lactiflora injection in treating chronic cor pulmonale with pulmonary hypertension]

The changes of clinical features of blood stasis, hemorheology, arterial blood gas and hemodynamics which was determined by impedance cardiogram and pheopneumogram, hemorheologic examination, blood gaseous analysis and right heart catheterization were observed in 42 patients (male 35, female 7; age 64 +/- 16.5 years), 32 patients with decompensative chronic cor pulmonale (CCP), served as noninvasive methods group (NMG) treated by intravenous injecting 100% Paeonia lactifiora injection 5 ml per day, 10 patients with CCP as well as pulmonary hypertension, which was proved through right heart catheterization were considered as invasive methods group (IMG) treated by pulmonary artery injecting 100% Paeonia lactiflora 5 ml (one-time). After the treatment, the clinical features of blood stasis were improved significantly in NMG (P less than 0.05). Also the results of impedance cardiogram and pheopneumogram (such as: Q-B, B-Y interval and Q-B/B-Y ratio, cardiac output), the hemorheologic parameters (such as: blood viscosity, plasma viscosity, hematocrit and erythrocyte electrophoresis) and oxygen consumption of myocardium were improved significantly in NMG and IMG. In IMG, PAP was reduced by 0.71 +/- 0.27 kPa; PaO2 was promoted significantly in NMG. All of these have statistical significance (P less than 0.05 or 0.01). There are no statistical significance about the change of PaCO2, SaO2, blood pH and Bp (P less than 0.05).