Alcohol Dehydrogenase in Drosophila melanogaster: Isozymes and Genetic Variants

Alcohol dehydrogenase, in Drosophila melanogaster homozygous for the alleles Adh(F) or Adh(S), is found in three electrophoretically different forms. Adh' differs from Adh(5) in that isozymes with faster electrophoretic mobilities are present. In Adh(F)/Adh(S) heterozygotes, hybrid isozymes as well as the parental isozymes are present, indicating that the dehydrogenase may exist as a dimer of two polypeptide subunits. The gene, Adh, is located on the second chromosome, with a map position of 50.1 and a cytological position between 34E3 and 35D1.