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Differential gene expression during multistage carcinogenesis.

G T Bowden¹, P Krieg

¹Department of Radiation Oncology, University of Arizona Medical School, Tucson 85724.

Environmental Health Perspectives

|June 1, 1991

Summary

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Mouse skin cancer research reveals key genes involved in tumor development. Stromelysin gene overexpression is linked to invasion and metastasis, offering potential therapeutic targets.

Area of Science:

Oncology
Molecular Biology
Carcinogenesis

Background:

Chemical carcinogenesis involves critical target genes, with Harvey-ras proto-oncogene activation in early mouse skin tumor initiation.
Ionizing radiation-initiated tumors exhibit different transforming genes compared to chemically initiated ones.

Purpose of the Study:

To identify cellular gene transcripts overexpressed during mouse skin tumor progression.
To understand the functional roles of differentially expressed genes in tumor development and metastasis.

Main Methods:

Utilizing a mouse skin multistage model of carcinogenesis.
Employing differential screening of cDNA libraries from chemically initiated malignant skin tumors.

Main Results:

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Identified overexpression of genes including beta-actin, ubiquitin, keratin K6, a fatty acid-binding protein, and stromelysin.
Stromelysin, a matrix metalloproteinase, showed overexpression, suggesting a role in basement membrane degradation.

Conclusions:

Overexpression of stromelysin is hypothesized to contribute to malignant tumor cell invasion and metastasis.
Characterizing differentially expressed genes may lead to the discovery of therapeutic targets for skin tumor progression.