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Human Achilles tendon: morphological and morphometric variations as a function of age
R Strocchi1, V De Pasquale, S Guizzardi
1Institute of Human Anatomy, University of Bologna, Italy.
Foot & Ankle
|October 1, 1991
Summary
Human Achilles tendon aging alters cellular and fibrous structures, leading to straighter fibers and variable collagen diameters. These age-related changes are likely linked to functional demands.
Area of Science:
- Biomedical Engineering
- Musculoskeletal Biology
- Connective Tissue Research
Background:
- Human Achilles tendon aging involves significant cellular and fibrous component alterations.
- Cellular changes include flattening, reduced numbers, and diminished cytoplasmic projections.
- Fibrous changes involve loss of undulation and increased collagen fibril diameter variability.
Purpose of the Study:
- To investigate the age-related morphological and morphometric changes in the human Achilles tendon.
- To correlate observed structural variations with functional requirements.
Main Methods:
- Morphological analysis of cellular and fibrous components.
- Morphometric analysis of collagen fibril diameter, density, and concentration.
- Evaluation of age-related changes from neonatal to adult stages.
Main Results:
- Aging tendons exhibit flattened, less numerous cells with reduced cytoplasmic projections.
- Tendon fibers become straighter with age, losing their typical undulating pattern.
- Collagen fibril diameter increases and becomes highly variable post-neonatal period, with decreased density and increased concentration.
Conclusions:
- Age-related morphological and morphometric variations in the Achilles tendon are significant.
- These structural changes are strongly associated with the tendon's functional requirements over time.