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Dd-antigen-antibody system in five caste groups in north India
The Indian Journal of Medical Research
|December 1, 1991
Summary
Human dandruff antigen Dd, a polymorphic marker, shows varied prevalence across North Indian populations. This inherited antigen, passed down through autosomal dominant inheritance, was studied in various caste groups.
Area of Science:
- Human genetics
- Immunodermatology
- Population genetics
Background:
- Antigen Dd is a polymorphic antigen identified in human dandruff extracts.
- Understanding its distribution is crucial for population genetics and dermatological studies.
Purpose of the Study:
- To investigate the prevalence and inheritance patterns of Antigen Dd in North Indian populations.
- To compare Antigen Dd frequencies among different caste groups.
Main Methods:
- Antigen Dd typing was performed on individuals from five North Indian caste groups.
- Family studies were conducted on 44 families to determine inheritance patterns.
Main Results:
- Antigen Dd prevalence varied significantly across groups, ranging from 21.21% in Brahmins to 29.08% in Jat Sikhs.
- Sunni Muslims in Kashmir exhibited a notably high frequency (45%), differing significantly from Punjabi groups.
- Family studies confirmed the inherited nature of Antigen Dd.
Conclusions:
- Antigen Dd exhibits significant population-specific variations in North India.
- The inheritance of Antigen Dd follows an autosomal dominant mode.
- Further research into the genetic and environmental factors influencing Antigen Dd distribution is warranted.